Search results for "4β hydroxycholesterol"

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Improved synthesis and in vitro evaluation of the cytotoxic profile of oxysterols oxidized at C4 (4α- and 4β-hydroxycholesterol) and C7 (7-ketocholes…

2013

Whereas the biological activities of oxysterols oxidized at C7 (7-ketocholesterol (7KC), 7β-hydroxycholesterol (7β-OHC), 7α-hydroxycholesterol (7α-OHC)) are well documented, those of oxysterols oxidized at C4 (4β-hydroxycholesterol (4β-OHC), 4α-hydroxycholesterol (4α-OHC)) are not well known, especially on the cells of the central nervous system. Therefore, an improved methodology has been validated for 4β-OHC and 4α-OHC synthesis, and the effects on cell viability and cell growth of these molecules were studied on immortalized, tumoral and normal brain cells (158N, C6 and SK-N-BE cells, and mixed primary cultures of astrocytes and oligodendrocytes). Whereas inhibition of cell growth with 7…

Central Nervous SystemCell SurvivalCentral nervous systemMolecular ConformationCell LineStructure-Activity RelationshipDrug Discoverypolycyclic compoundsmedicineHumansCytotoxic T cellViability assayKetocholesterolsCell ProliferationPharmacologyDose-Response Relationship DrugChemistryCell growthOrganic ChemistryGeneral MedicineHydroxycholesterolsIn vitroSterolsOn cellsmedicine.anatomical_structureBiochemistryToxicitylipids (amino acids peptides and proteins)sense organs4β hydroxycholesterolOxidation-ReductionEuropean Journal of Medicinal Chemistry

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